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I can't say much about BlazeDS... GraniteDS lets you customize the entire serialization process and has a quite unique feature with externalization and related code generation, see documentation...

You can use the GraniteDS implementations of big numbers (AS3) in your Flex code, with or without BlazeDS (just compile your code against granite.swc library). The all problem is with serialization...

As far as I know, BigDecimal / BigInteger and even reliable Java Long support for Flex is only implemented in GraniteDS, see documentation here. However, you will have to switch from Spring/BlazeDS...

Certainly a bit off-topic, but did you consider using Spring/GraniteDS? It is a powerful alternative to Spring/BlazeDS and its development/maintenance isn't subject of Adobe (in)decisions.

Franck.